Genetic form of breast cancer
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Changes or mutations in DNA can cause normal breast cells to become cancer. Certain DNA changes are passed on from parents inherited and can greatly increase your risk for breast cancer. Hormones seem to play a role in many cases of breast cancer, but just how this happens is not fully understood. Normal breast cells become cancer because of changes mutations in DNA.
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Familial breast cancer
Inherited genes and cancer types | Cancer Research UK
Women with an aggressive, less-common type of breast cancer, known as triple-negative, versus a more common form of the disease, could be differentiated from each other by a panel of 17 small RNA molecules that are directly influenced by genetic alterations typically found in cancer cells. Pequeno Pri? The researchers in this study focused on Brazil, in particular, where an estimated 60, new cases of breast cancer were diagnosed in The scientists discovered that women with TNBC had specific alterations in copies of their genes that directly influenced the expression of 17 miRNAs compared to women with other forms of breast cancer who did not have these alterations. They also found that the expression levels of the majority of these miRNAs were associated with the tumor's clinical aggressiveness advanced grade and stage.
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Inherited genes and cancer types
Ovarian cancer is a disease that affects women. In this form of cancer, certain cells in the ovary become abnormal and multiply uncontrollably to form a tumor. The ovaries are the female reproductive organs in which egg cells are produced.
Women with a significant risk of breast cancer frequently have multiple first degree relatives affected by the disease at an early age or have one or more relatives with multifocal or bilateral breast cancer. These women also often have a family history of ovarian cancer and male relatives affected by breast cancer. Such families usually fulfill the criteria for hereditary breast and ovarian cancer syndrome see Table.